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This leads to the mediation of the transcription of NLRP3 and pro-IL-1, resulting in the production of many inactive inflammatory mediators, leading to subsequent protease cleavage and activation ( FA can also induce the direct activation of the NLRP3 inflammasome in macrophages

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In the second and fourth cycles, the animals were administered 6, 30, and 150 g/kg BPC157 saline solutions via single IM injections

Post-translational modifications such as phosphorylation at Ser129 further enhance its aggregation propensity and neurotoxicity (Goedert et al., 2017